Antibody blocker Heterophilic Blocking Reagent

blocker is a general term for a class of materials used to eliminate or reduce the interference of immunoassay. Its application in in vitro diagnostic testing can effectively reduce false positive or false negative detection results caused by immunoassay interference, help to improve the sensitivity and specificity of detection, and thus improve the clinical performance of diagnostic reagents.

common interferents mainly include heterophilic antibody (Heterophile Antibody, HA), rheumatoid factor (Rheumatoid Factors, RF), etc. During detection, a blocker is added to the sample diluent to fully bind the blocker to the interferer to block the binding of the interferer to the capture/labeling antibody for detection.

blockers are divided into passive blockers (traditional blockers, IgG antibodies of heterogeneous animals, competitive binding interferers) and active blockers (a component that can neutralize interferers specifically, actively and efficiently).