产品描述
Olmesartan medoxomil (olmesartan) is a relatively new antihypertensive agent belonging to the class of angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) whose tolerability and effectiveness in the treatment of essential hypertension have been shown in several trials and clinical studies. This article reviews current findings on the clinical use of olmesartan as an antihypertensive drug given as monotherapy and in combination treatment in both clinical trials and in clinical practice. Olmesartan as monotherapy or in combination drug treatment has shown greater efficacy than placebo, and similar or greater efficacy compared with other classes of antihypertensive agents. Combination therapy with olmesartan also offers significant advantages in BP control over monotherapy with the component agents. Indeed, non-comparator up-titration studies have demonstrated that, as recommended by guidelines, an aggressive treatment algorithm can bring most patients to BP targets. Early-onset antihypertensive therapy appears to provide long-term benefits by reducing the risk of cardiovascular disease, particularly stroke; the antihypertensive effects of olmesartan have been documented from as early as 2 weeks. In clinical practice, olmesartan is effective in both adult and elderly patients and in patients with systolic or diastolic hypertension, or with isolated systolic hypertension.